The threefold miseries means first, pertaining to the body and mind, and second, miseries inflicted by other living entities, and miseries by nature or higher authorities. Just like severe cold or severe heat or famine or earthquake. They are also miseries. This is beyond our control. So miseries which are beyond our control.
So far bodily disease, mental disturbance, we can get some remedy in our own way. We can go to a psychiatrist or we can go to a doctor and get some medicine and get relief. And so far miseries from other living entities, we can take protection, we can defend ourself. But so far miseries offered by the demigods, daiva, there is no remedy.
If there is all of a sudden here earthquake, oh, there is no remedy. You have to suffer. If there is, all of a sudden, there is inundation, you cannot. If there is, all of a sudden, there is thunderbolt, you cannot make any remedy. So threefold miseries are always there, either one or two or three.
So Sanātana Gosvāmī is presenting himself that, "People call me very learned man, but I am so learned that I do not know why I am suffering from these threefold miseries." These question do not arise. Actually, when people will come to the understanding, when they will inquire that, "Why I am suffering from the threefold miseries . . .?"
The threefold miseries is summarized in Bhagavad-gītā by four principles: janma-mṛtyu-jarā-vyādhi-duḥkha-doṣānudarśanam (BG 13.9).
If a man is actually learned and intelligent, he should always see before him that there are four kinds of distresses. What is that? The distress of taking birth, the distress of dying procedure, janma-mṛtyu, and distress of old age and distress of diseases.