It takes very long time to explain each and every word, but I tell you in summary, this life is subjected to three kinds of miseries, always—either bodily, mental, or some miseries inflicted by other living entities or by nature. So many things. At least one or two.
We must be under the subjugation of some kind of miseries. But if you become situated in your spiritual platform of life, brahma-bhūtaḥ, you immediately become joyful, prasannātmā. Brahma-bhūtaḥ prasannātmā (BG 18.54). And how one becomes prasannātmā? What are the symptoms? The symptoms are also stated, na śocati na kāṅkṣati: he has no more any demand for satisfying the senses, neither he has any lamentation for any loss.
This is prasannātmā, joyfulness. That joyfulness is your inherent quality as brahma, as soul. Ānanda-mayo 'bhyāsāt. You have heard of the Vedānta-sūtra. In that Vedānta-sūtra you'll find this sūtra, these codes are there. Ānanda-mayo 'bhyāsāt brahma.
The Vedānta-sūtra begins, athāto brahma jijñāsā. This life, this human form of life, is now meant for inquiring about Brahman. What is that Brahman, that is immediately answered: janmādy asya yataḥ (SB 1.1.1). Brahman is the supreme source from where everything emanates, or everything is born. So in the Vedānta-sūtra, and that is explained in the Śrīmad-Bhāgavatam.