Prabhupāda: Bhāgavata says, bhave 'smin kliśyamānānām avidyā kāma-karmabhiḥ. Avidyā. Avidyā means ass, no intelligence. He does not know what is life, what is the course of life, how things are going on. He does not know. The more he is increasing his unnecessary desires, he's making himself entangled. That he does not know. He has to take freedom from the repetition of birth and death, but he's becoming more and more entangled. Avidyā kāma-karmabhiḥ.
This is Bhāgavata. In one line, the whole material existence explained. This is literature. In one line, there is thousands years' research work. In one line. Bhave 'smin. Now this bhave 'smin, you make research. Asmin, in this world, taking birth. So you have to learn so many things on these two words: How the living entities are taking birth in this world. Wherefrom he's coming, where he's going. What is his business. So many things in these two words, bhave 'smin. Kliśyamānānām. Struggle for existence. Why? Avidyā. Ignorance. What is that avidyā? Kāma-karmabhiḥ.
Brahmānanda: Desire.
Prabhupāda: Activities of sense gratification. He's becoming entangled.
Svarūpa Dāmodara: So the modern scientific research means to increase the demands of the body, the bodily demands.
Prabhupāda: Yes, what they can do? Because they're rascal, foolish, just like children, they'll simply make their body dirty. That's all. He does not know anything. If you bring a small children, what they will do? They'll take this . . . you see. He does not know anything. He's a rascal.