By understanding the Lord's simultaneous oneness with and difference from His creation, one can immediately attain freedom from the threefold miseries—miseries inflicted by the body and mind, by other living entities, and by acts of nature, over which we have no control.
Śrīmad-Bhāgavatam begins with the surrender of the living entity unto the Absolute Person. This surrender is made with full awareness of the devotee's oneness with the Absolute Person and, at the same time, his eternal position of servitorship toward Him. In the material conception one falsely thinks himself the Lord of all he surveys; consequently he is always troubled by the threefold miseries of life. But as soon as one comes to know his real position in transcendental service, he at once becomes freed from all the above-mentioned threefold miseries.