Prabhupāda: So when Sanātana Gosvāmī approached Śrī Caitanya Mahāprabhu to become His disciple, he inquired from Him, tattva-jijñāsā. (to translator, Mahāṁśa Swami:) Shall I stop here?
Mahāṁśa Swami: (indistinct)
Prabhupāda: Who is the disciple? Sanātana Gosvāmī. (break) So this Sanātana Gosvāmī, when (he) approached Caitanya Mahāprabhu... That is the system. We sometimes accept one guru. But why should we accept guru? What is the necessity of accepting guru? This is the necessity for tattva-jijñāsā, for inquiring about the Absolute Truth. Tad-vijñānārthaṁ sa gurum eva abhigacchet, samit-pāṇiḥ śrotriyaṁ brahma-niṣṭham (MU 1.2.12). This is the Vedic injunction. Simply if we remain engaged in the four activities of this material body, namely eating, sleeping, sex life, and defense, then we are animals. Our human life should be executed with the aim of life.
The aim of life is tattva-jijñāsā. That Sanātana Gosvāmī did when he approached Śrī Caitanya Mahāprabhu. He inquired from Him, ke āmi kene āmāya jāre tāpa-traya: "My dear Lord, kindly let me know who am I and why I am put into the threefold miserable condition of life." Then one can say, "You are minister. You know what you are." Then he says, "No, actually I do not know what I am." Grāmya-vyavahāre paṇḍita tāi satya māni: "Some neighborhood men, they call me I am very big man, I am very learned man, and when I study myself," āpanāra hitāhita kichui nā jāni, "I do not know what I am, wherefrom I have come, where I have to go after leaving this body, why I am put into the tribulation of threefold miseries. I do not want to die. Why death is enforced upon me? I do not want to take birth. Why that is also enforced upon me? I do not want old age. Why it is enforced upon me? I do not want disease. Why it is enforced upon me? And what is the purpose of my coming in this material world, and where I shall go after my death? Or this is the finish?" There are so many things to inquire. That is called tattva-jijñāsā. This is called tattva-jijñāsā. Jīvasya tattva-jijñāsā.